Green tea extracts suppress oxidative stress induced by dietary lipid peroxidation products
نویسندگان
چکیده
Green tea and its components possess antioxidative effects in vivo and in vitro. In this study, suppressive effects of green tea extracts on oxidative stress induced by dietary lipid peroxidation products were investigated in the rat liver in vivo. Green tea extracts (10 mg/rat/day for 3 days) were orally administered to male Wistar rats (five-week-old) 10 minutes prior to the post-oral administration of secondary autoxidation products of linoleic acid (400 mg/rat/day for 3 days). Control rats were given saline solution instead of green tea extracts and/or the secondary products. Green tea extracts prevented body weight loss caused by the secondary products. The effects of green tea extracts on oxidative stress were investigated 24 hours after the third dose. Green tea extracts showed the significant decreases in the amounts of thiobarbituric acid reactive substances and the levels of 4-hydroxynonenal and n-hexanal in rats dosed with the secondary products. Moreover, the extracts protected hepatic dysfunction as estimated by measuring the activity of five enzymes, which were specifically inactivated by the secondary products. These results clearly demonstrated that green tea extracts suppress both oxidative stress and hepatic dysfunction induced by dietary lipid peroxidation products.
منابع مشابه
Effect of dietary green tea catechin preparation on oxidative stress parameters in large intestinal mucosa of rats.
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